Study selection and eligibility criteriaWe included original peer reviewed reports of observational studies and clinical trials if published in full text or if we had full access to all original data and protocols. We excluded studies that were published only as abstracts or conference reports. We considered reports that evaluated the association of reduced function and increased function genetic variants of CYP2C19 with the occurrence of clinical outcomes in patients with established coronary artery disease who were treated with clopidogrel. Two researchers (DT and TB) independently retrieved studies. The strength of agreement was measured by Cohen’s coefficient with approximate ralph lauren kids t shirt
standard errors,21 with =0.41 0.60 indicating moderate agreement, 0.61 0.80 good agreement, and 0.81 representing very good agreement.22 Disagreements were resolved by consensus.
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